Progesterone occurs as a white or creamy white, crystalline powder. Dose: 50 mg / 300 mg / 200 mg / 500mg. Initial dose: 100 mg vaginally 2 to 3 times a day, starting the day after oocyte retrieval It is important to change the location of the injection site daily to avoid problem areas in the muscle.Use this medication regularly to get the most benefit from it. There are three main sex hormones in females. Hepatic Insufficiency: The safety and effectiveness in patients Progesterone … If any of these warning signals (or any other unusual symptoms) happen while you are using Progesterone Injection, call your doctor immediately: Progesterone Injection is intended for administration by injection into a muscle mass. The metabolism of progesterone by human liver microsomes was inhibited by ketoconazole Get information on Progesterone injection including uses, dosage details, medication side-effects and drug interaction facts from Cleveland Clinic's health library. -Estrogens plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia. FDA Rev date: 1/9/2007. *If you experience sleepiness, do not drive or operate machinery. Nursing Mothers: Detectable amounts of drug have been identified in Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for PROGESTERONE. or speech, weakness or numbness of an arm or leg indicating possible clots menstrual irregularities. Since progesterone metabolites The upper outer quadrant of the buttocks is the preferred site for injection if someone else is giving you the injection. Progesterone at high doses is an antifertility drug and high doses would be expected to impair fertility until the cessation of treatment. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever the solution and container permit. with renal insufficiency have not been established. last injection. this drug to anyone else. Less reliable are: Prometrium (oral tablets, also prescribed for vaginal use, 200 mg 1-2x/day) Progesterone suppositories (200 mg 1-2x/day, compounded by a pharmacy. doctor. Because of the body’s rapid metabolism of progesterone, the shot should be given daily to maintain adequate blood progesterone … It is a progestogen and is used in combination with estrogens mainly in hormone therapy for menopausal symptoms and low sex hormone levels in women. Also Debold and co-workers (DeBold et al., 1978) reported that simultaneous injections of progesterone … In sesame oil Store at 15 to 30 degrees celsius (59 to 86 degrees fahrenheit) More … Log in for pricing and availability. Your doctor has prescribed this drug for you and you alone. -If ovarian activity is sufficient to produce a proliferative endometrium, withdrawal bleeding is expected 48 to 72 hours after the last injection. This is the daily IVF routine during the progesterone injection time. Gautam Budh Nagar 512, 5th Floor, The I-thum, Tower-B, Plot no. -The Women's Health Initiative (WHI) estrogen plus progestin substudy reported increased risks of deep vein thrombosis, pulmonary embolism, stroke and myocardial infarction in postmenopausal women (50 to 79 years of age) during 5.6 years of treatment with daily oral conjugated estrogens (CE) [0.625 mg] combined with medroxyprogesterone acetate (MPA) [2.5 mg], relative to placebo. The injection can at time result in painful sore on the sites of the injection. How Supplied Progesterone Injection, USP 50 mg/mL is available in 10 mL multiple dose vials. The dosage used may be important in minimizing these adverse effects. on the vial label. This may be followed by spontaneous normal cycles. Breast Cancer This medication is given by injection into a muscle as directed by your doctor, usually once daily. Renal Insufficiency: The safety and effectiveness in patients Keep this and all drugs out of the reach of children. DOSAGE & INDICATIONS Intramuscular dosage. Because progestational drugs may cause some degree of fluid retention, conditions which might be influenced by this condition, such as epilepsy, migraine, asthma, cardiac, or renal dysfunction, require careful observation. There can be breast tenderness, pain or swelling at the site of injection, weight gain, weight loss, headache, and increase in … Setting: Physiopathology of Human Reproduction Unit, Pordenone, Italy, from July 2000 to June 2004. Packaging Type: Box. Take out a 3 ml syringe and apply a sterile 22 gauge needle before giving yourself the injection. Should any of these occur or be suspected, the drug For functional uterine bleeding, administer five to 10 mg daily for six doses. ORAL Tablets: Micronized Progesterone (Prometrium®), 100 mg PO BID; or Medroxyprogesterone (Provera®), 5 - 10 mg PO qD One possible regimen: start with a moderate estrogen dose (e.g., estradiol, 2 mg BID); one month later, advance to a higher dose (e.g., estradiol, 6-8 mg qD, divided doses); one month later, add spironolactone, 100 mg BID or TID. Progesterone injections must be given in a muscle, while vaginal progesterone comes in capsule or gel form. There are possible risks which may be associated with the use of progestin treatment, including adverse effects on carbohydrate and lipid metabolism. It will pull into the syringe more slowly than sterile water does as when you use your other fertility medications. Visit the FDA MedWatch website or call 1-800-FDA-1088. Abnormal blood clotting.