2014 Aug 12;19(8):12078-98. doi: 10.3390/molecules190812078. 70. This work demonstrates a proof-of-concept of singlet oxygen-based chemodynamic therapy for selective tumor eradication, which produces a novel trigger-free, singlet oxygen-based cancer therapy without the side effects of traditional photodynamic and sonodynamic therapy. SingloTex™ utilizes an organic dye to react with light to produce what’s known as Singlet Oxygen. Cardiac toxicity of singlet oxygen: implication in reperfusion injury. Keywords: Epub 2014 Nov 30. Wang P, Liang C, Zhu J, Yang N, Jiao A, Wang W, Song X, Dong X. ACS Appl Mater Interfaces. We used Photofrin as a source of 1O2. eCollection 2020. 2017, 56, 7519). Fig. 2016 May;28(17):3313-20. doi: 10.1002/adma.201505869. However, some toxicity has also been reported to occur in the dark. [Free oxygen radiacals and kidney diseases--part I]. In the fluorescent (flu) mutant, its release causes seedling lethality and inhibits mature plant growth. Author links open overlay panel Jiaoxue Yang a Guochun Lv a Zehua Wang a Xiaomin Sun a Jian Gao b. Rev. These radicals damage the capillary membrane increasing capillary permeability and ARDS like picture. Mechanisms, kinetics and eco-toxicity assessment of singlet oxygen, sulfate and hydroxyl radicals-initiated degradation of fenpiclonil in aquatic environments. Environmental Science & Technology 46: 12098-104. It is a natural antimicrobial agent, delivering superior protection against odor-causing bacteria. Epub 2019 Oct 23. USA.gov. We also determined the 1O2 quenching constants for these compounds and their values were on the order of 10(6) M-1 s-1, except for lomefloxacin whose rate constant was 1.8 x 10(7) M-1 s-1. It is postulated that the concurrent delivery of ascorbate and nanoparticulate hypochlorous ion (ClO - ) could produce singlet … Ascorbate at the pharmacological concentration could accumulate hydrogen peroxide only in the tumor site. Abstract Traditional singlet oxygen‐based antitumor therapies have been burdened with the necessity of external energy (e.g., light and ultrasound) and harmful dark toxicity. radical ions) and type II (singlet oxygen) sensitized oxidation processes.9,10 The “ene” hydroperoxide products serve as fingerprints for the existence of 1O 2 and have dark stabilities in the milliseconds to minutes time range. This site needs JavaScript to work properly. 2019 Feb 27;11(8):7731-7742. doi: 10.1021/acsami.8b19840. Singlet oxygen plays a role in cellular stress either by providing direct toxicity or through signaling to initiate death programs. Abstract Singlet oxygen (1 O 2), the major reactive oxygen species (ROS) produced in chloroplasts, has been demonstrated recently to be a highly versatile signal that induces various stress responses. Singlet oxygen radicals generated during the photo-bleaching of fluorescent dyes is a serious problem that limits the usefulness of fluorescence microscopy in studying molecular process in living cells. The phototoxicity order reported in humans is: fleroxacin > lomefloxacin, pefloxacin >> ciprofloxacin > enoxacin, norfloxacin and ofloxacin. Ascorbate at the pharmacological concentration could accumulate hydrogen peroxide only in the tumor site. Structure and medium-dependent photodecomposition of fluoroquinolone antibiotics. 2015 Mar;401(1-2):107-14. doi: 10.1007/s11010-014-2297-7. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence. It was therefore of interest to examine cell death, as occurs in Arabidopsis, due to differentially localized singlet oxygen photosensitizers. Studies both in vivo and in vitro have related this phototoxicity to the generation of reactive oxygen species including hydrogen peroxide and the hydroxyl radical.  |  Umezawa N, Arakane K, Ryu A, Mashiko S, Hirobe M, Nagano T. Arch Biochem Biophys. S-allylcysteine scavenges singlet oxygen and hypochlorous acid and protects LLC-PK(1) cells of potassium dichromate-induced toxicity. This site needs JavaScript to work properly. Controlled Release 2017, 260, 12; b) P. Huang, X. Qian, Y. Chen, L. Yu, H. Lin, L. Wang, Y. Zhu, J. Shi, J. However, due to the highly efficient intersystem crossing potency to generate singlet oxygen (1 O 2), high-efficiency photosensitizers often suffer from weak fluorescence and excess injury to normal tissue. Am. (1)Institute of Pharmacology and Toxicology, University of Würzburg, Germany. Singlet oxygen refers to one of two singlet electronic excited states. Herein, subscript A denotes the acidic form of the complex bearing OH groups, and B denotes the basic form bearing O- groups. We also measured the photogeneration (lambda > 300 nm) of superoxide by these antibacterials in dimethylsulfoxide using electron paramagnetic resonance and the spin trap 5,5-dimethyl-1-pyrroline N-oxide. Singlet oxygen can inactivate proteins within a few nanometers of the photobleached fluorophore [10,21]. The research, published in the journal Scientific Reports is based on the successful quantification of singlet oxygen produced during photodynamic therapy for cancer. Singlet Oxygen is nature’s defense against bacteria.  |  The singlet oxygen (1 O 2) generation capacity of TAPP can be activated and significantly enhanced at acidic pH (4.5–5.0). Ma S, Zhou J, Zhang Y, Yang B, He Y, Tian C, Xu X, Gu Z. ACS Appl Mater Interfaces. Chem. HHS Exposure of nine different leukemia cell lines (CEM, HEL, HL-60, K-562, KG-1, L1210, Molt-4, THP-1 and U-937) to Photofrin and light results in changes in membrane permeability (trypan blue) that vary with cell line. Nanomedicine. Reactive oxygen species (ROS) including singlet oxygen (¹O₂) and hydroxylradicals (OH) photogenerated in natural waters play important roles in indirect photolysis of man-made pollutants. 1998 Aug 21;45(1):51-9. doi: 10.1016/S1011-1344(98)00160-2. Oxygen is a colourless, odourless, tasteless gas and makes up 20.98% of air by volume. Rhamnolipid nanoparticles for in vivo drug delivery and photodynamic therapy. 2017, 139, 1275. Flumequine-Mediated Upregulation of p38 MAPK and JNK Results in Melanogenesis in B16F10 Cells and Zebrafish Larvae. 2020 Mar 10;11:226. doi: 10.3389/fphar.2020.00226. Singlet oxygen is the major species participating in the induction of DNA strand breakage and 8-hydroxydeoxyguanosine adduct by lead acetate. The ClO- is loaded in a hybrid core-shell nanocarrier consisting of a zeolitic imidazolate framework and amphiphilic poloxamer 188. Participation of reactive oxygen species in phototoxicity induced by quinolone antibacterial agents. Biomolecules. Vitamin D Pretreatment Attenuates Ciprofloxacin-Induced Antibacterial Activity. This is an excited form of oxygen in which one of the electrons jumps to a superior orbital following absorption of energy. Airborne singlet oxygen obtained from photosensitization of triplet dioxygen is shown to react with an alkene surfactant (8-methylnon-7-ene-1 sulfonate) leading to "ene" hydroperoxides that in the dark inactivate planktonic Escherichia coli (E. coli).The "ene" hydroperoxide photoproducts are not toxic on their own, but they become toxic after the bacteria are pretreated with singlet oxygen. Singlet oxygen sensor green (SOSG) shows the formation of 1O2 in cell culture for cells treated with 3A and blue light. Yasuhiko Sawaki and Christopher S. Foote, "Acyclic Mechanism in the Cleavage of Benzils with Alkaline Hydrogen Peroxide" J. Amer. Guo S, Yao X, Jiang Q, Wang K, Zhang Y, Peng H, Tang J, Yang W. Front Pharmacol. 2001;34(2):237-56. doi: 10.1385/CBB:34:2:237. Barbieriková Z, Dvoranová D, Bella M, Milata V, Czímerová A, Brezová V. Molecules. The production of 1O2 by these antibiotics did not correlate with the order reported for their phototoxicity. Singlet Oxygen Therapy is able to harness the power of photosynthesis to trigger the body’s own natural healing and balancing mechanisms. Chem. Oxygen Toxicity depends on alveolar concentration (not on arterial concentration). Singlet oxygen, 1O2 (1 delta g), fulfills essential prerequisites for a genotoxic substance, like hydroxyl radicals and other oxygen radicals: it can react efficiently with DNA and it can be generated inside cells, e.g. Environ Mol Mutagen 33:194-201 10334621. (Books and Publications: Peer Reviewed Article) 2012 Under most common laboratory conditions, the higher energy Σ g singlet state rapidly converts to the more stable, lower energy Δg singlet state. Epub 2019 Apr 12. Crossref, Medline, Google Scholar; Yin L, Morita A, Tsuji T. 2001. Pathophysiology: Toxicity with oxygen is because of toxic radicals of oxygen like superoxide and hydroxyl ions, singlet oxygen, hydrogen peroxide. Dark toxicity was assessed in vitro and in vivo. The singlet states of oxygen are 158 and 95 kilojoules per molehigher in energy than the triplet ground state of oxygen. Therefore, all divers should have at least a basic understanding of oxygen toxicity. Oxygen-derived radicals are generated constantly as part of normal aerobic life. by photosensitization and enzymatic oxidation. 2019 Oct 11;9(10):596. doi: 10.3390/biom9100596. Chem. Manganese-Based Nanoplatform As Metal Ion-Enhanced ROS Generator for Combined Chemodynamic/Photodynamic Therapy. Effect of norfloxacin and moxifloxacin on melanin synthesis and antioxidant enzymes activity in normal human melanocytes. NCI CPTC Antibody Characterization Program. Qian C, Yu J, Chen Y, Hu Q, Xiao X, Sun W, Wang C, Feng P, Shen QD, Gu Z. Adv Mater. Fluoroquinolone antimicrobials: singlet oxygen, superoxide and phototoxicity. "Bacterial Inactivation by a Singlet Oxygen Bubbler: Identifying Factors Controlling the Toxicity of Singlet O 2 Bubbles." Christopher S. Foote, "Quenching of Singlet Oxygen" in Singlet Oxygen, Edited by H. H. Wasserman and R. W. Murray, 139-171 (1979), Academic Press, New York. USA.gov. All the fluoroquinolones examined have low phi delta values ranging from 0.06 to 0.09 in phosphate buffer at pD 7.5.  |  Author information: (1)Laboratoire Stress Cardiovasculaires et Pathologies Associées, Université Joseph Fourier, Bâtiment Jean Roget, Domaine de … Clipboard, Search History, and several other advanced features are temporarily unavailable. This photocytotoxicity was originally attributed to photodissociation, but recent results suggest that singlet oxygen formation is a more plausible cause of photocytotoxicity. Reactive oxygen species (ROS) are highly reactive chemical molecules formed due to the electron acceptability of O 2.Examples of ROS include peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen.. The fluoroquinolone antibacterial agents possess photosensitizing properties that lead to phototoxic responses in both human and animal subjects. The phototoxicity order reported in humans is: fleroxacin > lomefloxacin, pefloxacin >> ciprofloxacin > enoxacin, norfloxacin and ofloxacin. Nevertheless, the magnitudes of the observed differences do not appear sufficient to explain the range of fluoroquinolone phototoxicity potencies in human and animal subjects in general and the high activity of fleroxacin and lomefloxacin in particular. In the case of fluorescein-labeled tubulin, these radicals sever microtubules. Upon intravenous nanocarriers delivery plus intraperitoneal ascorbate administration to xenograft mice, the in vivo antitumor efficacy of this cooperative nanomedicine is demonstrated without noticeable side-effects. S7a and b,† the signal of annexin FTIC/PI cannot be observed in blank or dark groups, indicating that P1 has low toxicity without light irradiation. Traditional singlet oxygen-based antitumor therapies have been burdened with the necessity of external energy (e.g., light and ultrasound) and harmful dark toxicity. The phi delta values were significantly decreased in a solvent of lower polarity such as methanol (0.007 < or = phi delta < or = 0.02). 2010 Jun;6(3):486-95. doi: 10.1016/j.nano.2009.11.004. Cell Biochem Biophys. Photocleavage of DNA by the fluoroquinolone antibacterials. Most graphene-like structure catalyst activate PMS through a non-radical route with ROS of singlet oxygen (1 O 2), this may be one of the reasons why more 1 O 2 contributed to the degradation of SMX in RSDBC/PMS system, which was discussed in … Photochem Photobiol.  |  © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Would you like email updates of new search results? National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. The toxicity of oxygen is a function of … Beberok A, Wrześniok D, Otręba M, Miliński M, Rok J, Buszman E. Mol Cell Biochem. Singlet oxygen-induced apoptosis of cancer cells using upconversion fluorescent nanoparticles as a carrier of photosensitizer. Online ahead of print. To overcome these obstacles, here we show a reliable self-reporting strategy for real-time monitoring of therapeutic progression. 2019 Jul;19:12-21. doi: 10.1016/j.nano.2019.03.015. Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy. Nanomedicine. The two singlet states are denoted Σ g and Δg (the preceding superscript "1" indicates a singlet state). Cancer Inst. COVID-19 is an emerging, rapidly evolving situation. Epub 2016 Mar 7. It is postulated that the concurrent delivery of ascorbate and nanoparticulate hypochlorous ion (ClO- ) could produce singlet oxygen at the tumor site as an energy-free, tumor-specific therapy. Epub 2019 Feb 12. 2020 Dec 19;21(24):9714. doi: 10.3390/ijms21249714. NLM Clipboard, Search History, and several other advanced features are temporarily unavailable. Prevention and treatment information (HHS). Karunarathne WAHM, Molagoda IMN, Kim MS, Choi YH, Oren M, Park EK, Kim GY. Cite. Show more. Formation of Reactive Oxygen Species.  |  Ascorbate at the pharmacological concentration could accumulate hydrogen peroxide only in the tumor site. 1998 Nov;68(5):666-74. The reduction of molecular oxygen (O 2) produces superoxide (• O − 2), which is the precursor of most other reactive oxygen species:. Besides, the enhanced near-infrared absorption of TAPP at acidic pH enabled a further increase in 1 O 2 generation capability by a near-infrared laser (760 nm). Fused-ring derivatives of quinoxalines: spectroscopic characterization and photoinduced processes investigated by EPR spin trapping technique. Epub 2010 Jan 4. Cancer 2003, 3, 380; c) S. J. Dixon, K. M. Lemberg, M. R. Lamprecht, R. Skouta, E. M. Zaitsev, C. E. Gleason, D. N. Patel, A. J. Bauer, A. M. Cantley, W. S. Yang, B. Morrison, B. R. Stockwell, Cell 2012, 149, 1060. a) X. Li, M. Gao, K. Xin, L. Zhang, D. Ding, D. Kong, Z. Wang, Y. Shi, F. Kiessling, T. Lammers, J. Cheng, Y. Zhao, J. ascorbates; chemodynamic therapy; metal organic frameworks; nanoparticles; singlet oxygen. Please enable it to take advantage of the complete set of features! COVID-19 is an emerging, rapidly evolving situation. Would you like email updates of new search results? Toufektsian MC(1), Boucher FR, Tanguy S, Morel S, de Leiris JG. 2021 Feb 10. doi: 10.1021/acs.biomac.0c01679. We determined the quantum yields of singlet oxygen generation (phi delta) by detection of the singlet oxygen (1O2) luminescence at 1270 nm for several fluoroquinolones, naphthyridines and other structurally related compounds.  |  An Oxygen Self-sufficient Fluorinated Nanoplatform for Relieved Tumor Hypoxia and Enhanced Photodynamic Therapy of Cancers. These longer dives also increase the risk of O2 toxicity. NIH For these latter drugs the photoinduced loss of the F8 atom as fluoride and the concomitant generation of a highly reactive carbene at C-8 provide a more plausible mechanism for their potent phototoxic and photocarcinogenic properties. The plant photosensitizer alpha-terthienyl (αT) is toxic toward a variety of organisms, and normally requires exposure to ultraviolet-A radiation for activation and singlet molecular oxygen formation. Despite their superior properties over standard photosensitizers, QDs exhibit low singlet oxygen quantum yield, cause cytotoxicity from the release of heavy metal ions (e.g., Cd2+), and can undergo degradation in cells, all of which impede their practical application [ 11, 13 ]. Because cell lines can have different PUFA and protein levels, we hypothesized that 1O2 toxicity will vary between cell lines. eCollection 2020. Share. 2015CB856500/National Basic Research Program of China/International, 18JCZDJC35700/Tianjin Research Program of Application Foundation and Advanced Technology/International. Singlet Oxygen Therapy with Valkion® is a highly advanced, safe, non-invasive, non-toxic therapy. Traditional singlet oxygen-based antitumor therapies have been burdened with the necessity of external energy (e.g., light and ultrasound) and harmful dark toxicity. 1997 Jun 15;342(2):275-81. doi: 10.1006/abbi.1997.0124. Although there is not a one-to-one correspondence between the relative rates of superoxide generation and the phototoxicity ranking of the fluoroquinolones, the more phototoxic compounds tended to produce superoxide at a faster rate. This more stable of the two excited states has its two valence electrons spin-paired in … NLM Singlet Oxygen and its miraculous properties are why we named our company Singlotech. Prevention and treatment information (HHS). 2019 Nov 6;11(44):41140-41147. doi: 10.1021/acsami.9b16617. a) T. J. Dougherty, C. J. Gomer, B. W. Henderson, G. Jori, D. Kessel, M. Korbelik, J. Moan, Q. Peng, JNCI, J. Natl. Materials & methods: Physicochemical characteristics of GQDs were comprehensively investigated, including electron paramagnetic resonance analysis of singlet oxygen production. Another radical derived from oxygen is singlet oxygen, designated as 1 O 2. Please enable it to take advantage of the complete set of features! PDT-Enhanced Ferroptosis by a Polymer Nanoparticle with pH-Activated Singlet Oxygen Generation and Superb Biocompatibility for Cancer Therapy Biomacromolecules. Intracellular singlet oxygen production is verified in 4T1 cells by the cooperation between hybrid nanocarriers and ascorbate, which induces significant apoptotic cell death. 2020 Oct 12;12:171-176. doi: 10.2147/CPAA.S268330. 1998, 90, 889; b) D. E. Dolmans, D. Fukumura, R. K. Jain, Nat. Medina-Campos ON(1), Barrera D, Segoviano-Murillo S, Rocha D, Maldonado PD, Mendoza-Patiño N, Pedraza-Chaverri J. Molecular and Biochemical Basis of Fluoroquinolones-Induced Phototoxicity-The Study of Antioxidant System in Human Melanocytes Exposed to UV-A Radiation. At physiological pH, complexes 1A-3A are deprotonated to form 1B-3B in situ. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Masadeh MM, Alzoubi KH, Al-Taani BM, Masadeh MM, Aburashed ZO, Alrabadi N. Clin Pharmacol. Dihydroartemisinin-Loaded Magnetic Nanoparticles for Enhanced Chemodynamic Therapy. J Photochem Photobiol B. O 2 + e − → • O − NIH Soc ., 101 , 6292-6296 (1979). Soc. The fluoroquinolone antibacterial agents possess photosensitizing properties that lead to phototoxic responses in both human and animal subjects. Kowalska J, Banach K, Rok J, Beberok A, Rzepka Z, Wrześniok D. Int J Mol Sci. HHS
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